Tissue digoxin concentrations and digoxin effect during the quinidine-digoxin interaction
نویسندگان
چکیده
منابع مشابه
Quinidine-digoxin interaction: cardiac efficacy of elevated serum digoxin concentration.
Cardioactivity due to elevated serum digoxin concentration (SDC) after quinidine (Q) and digoxin (D) was evaluated in six healthy subjects by means of measurement of systolic time intervals (STIs). Each subject randomly received basic treatments with 0.2 mg D and placebo (PL1). Randomized coadministrations with Q (1 gm/day), sparteine (SP) (0.8 gm/day), and placebo (PL2) were given for 7-day pe...
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paras), and to attend a clinic or return the questionnaire after three months. Fifty-two patients (87 %) (15 primiparas and 37 multiparas) completed questionnaires. They were matched with a control group of 52 vaccinated patients who received no hormonal treatment. The mean (i SD) number of days of postpartum bleeding was 58-5 i 18-5 in the treated patients and 20-8 1-1 in the controls. This di...
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To investigate the basis for a clinically important digitalis-quinidine interaction that is characterized by increases in serums digoxin concentrations when quinidine is administered to digoxin-treated patients, we have studied in vitro the interaction of quinidine with the digoxin receptor. Evidence has been obtained that quinidine is capable of decreasing the affinity for digoxin of cardiac g...
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those needing to abstain may unwittingly drink if they believe low alcohol drinks to be effectively alcohol free. Others wanting to limit their drinking by counting units may drink far more than their chosen amounts if they fail to make adjustments for extra strong drinks. There are two possible strategies for minimising these errors. Firstly, all drinks could have their alcohol content clearly...
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We evaluated the effect of quinidine on digoxin pharmacokinetic in six patients with severe renal failure. Quinidine reduced the total body clearance of digoxin from 1.87 to 1.06 l/hour (p less than 0.001), and prolonged the digoxin half-life of elimination from 5.20 to 9.61 days (p less than 0.01). The digoxin volume of distribution was unchanged. Renal clearance of digoxin was negligible; thu...
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ژورنال
عنوان ژورنال: Journal of the American College of Cardiology
سال: 1985
ISSN: 0735-1097
DOI: 10.1016/s0735-1097(85)80394-6